The bulk of the alpha-glucosidase activity in semen, and more particular that of its neutral iso-enzyme (NAG), depends on secretion by the epididymis. In patients with azoospermia and normal androgen levels in peripheral blood, NAG activity in semen plasma is a reliable marker of the epididymal contribution to the ejaculate.

Low NAG activity in seminal plasma of patients with oligozoospermia may reflect partial obstruction of the epididymides, associated with infections or inflammatory disease. Enzyme activity in patients with normal sperm concentration is correlated with the result of the Shorr-stain of midpiece and tail, reflecting changes in cell membrane, induced by epididymal secretion. The EpiScreen Plus assay may assist in the diagnosis and the management of male infertility.

EpiScreen Plus has a 24 month shelf life from production date. Information about the composition of the product can be found in the material safety data sheet.